"The present invention provides novel polypeptides which are substantially
free of a B. burgdorferi spirochete or fragments thereof and which are thus
useful in compositions and methods for the treatment and prevention of B.
burgdorferi infection and Lyme disease. In one preferred embodiment, this
invention provides modified OspA polypeptides and pharmaceutically effective
compositions and methods comprising those polypeptides. Preferred modified OspA
polypeptides are characterized by modifications which diminish and/or ablate
their ability to bind the human MHC allele HLA-DRB1*0401. "