Steere says in this 1986 article that
there is no data regarding the changing
and expanding IgM and IgG responses in
REALLY, Allen ?
Nothing needs to be said, just read
this. This was the original and
true observation. The disease was later spun to sell a
3 Times is a Charm:
At the 1994 FDA Lyme vaccines meeting,
Raymond Dattwyler said it (pages
43 – 47) See also below the
scanned in Steere Antigens article here; In
discussing how to assess Lyme diagnosis
and vaccine response, paragraph 4
of the meeting minutes transcript:
what serologic assays could one use in
a study such as a vaccine trial.
Would a single ELISA be adequate.
Would a single Western Blot be
adequate. Or, should one do
serial ELISAs and serial Western
It is my
opinion that the best way to assess
most infectious diseases is to get
acute and convalescent serology.
If one thought that the person was
acutely infected, I think that is a
classic way of assessing.
that, if you immunize someone with a
vaccine and get an appropriate immune
response, that they should have some
antibody and perhaps be positive in a
single ELISA. So, a single ELISA
under those circumstances, I don’t
think, wuold be terribly useful.
Western Blot, since we are immunizing
– at least in this discussion – with
OspA, would that be useful. The
answer is, I think, yes, and I will
get back to that in a minute.
ELISA certainly could be helpful if
one did it in an acute and
convalescent. A rising serologic
response would suggest an infection.
And the same, I think would be true
about serial Western Blots, where one
would see an increase in repertoire of
immune response against various
antigens to the bacteria….”
2) Below, Steere
3) Steve Schutzer's Book,
Dattwyler and Luft Chapter.
RAY DATTWYLER AT THE 1994 FDA VACCINE
MEETING: RECOMMENDING SERIAL
WESTERN BLOTS TO LOOK FOR CHANGING,