24 May 2012
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"Bacterial/Viral Coinfections";
TLR2 (fungi)Signaling Depletes IRAK1 and Inhibits Induction of Type 1 by TLR7/9 (viruses)-- -CV Harding, 2012 (More in the chart at the bottom of this homepage)
"Multiple Mechanisms of Immune Suppression by B Lymphocytes" (New and Trashes Yale and IDSA)
NIH's Treatment Recommendations for Chronic Active Epstein-Borreliosis, the chronic illness also induced by OspA vaccination or exposure to molds.
ELISA = arbitrary cutoff.
Disclaimer
1998, CIA Oilmen & Israelis plan to overthrow Saddam for the oil.
Bush/Gore Oil/War-(Oct,2000)
Bush's own explainer (Oct
2000) re:
Iraq Oil
PSYCHIATRIC MISDIAGNOSES: No one who has Lyme can be diagnosed as "Bipolar." The same is true for Multiple Sclerosis. MS is a rule-out for Bipolar according to the DSM-IV.
Lyme is a brain disease, so no one with Lyme can be diagnosed with anything "psychiatric" and all Lyme victims should stay away from psychiatrists.
From the text of the NIH Clinical Trial below:
"4. Needlestick to collect 3 tablespoons of blood to measure blood count and thyroid levels, liver and kidney function, to test the immune system and check for certain diseases, such as Lyme disease."
See- Brian Fallon @ www.columbia-lyme.org This is a published chapter in the Sadock's 2002 Comprehensive Textbook of Psychiatry.
Ruling out Lyme disease in Bipolar disorder in children and Adolescents:
http://www.clinicaltrials.gov/ct/gui/show/NCT00006177?order=1
- Study ID Numbers 000198; 00-M-0198
Home | Search | Browse | Resources | Help | What's New | About Symptoms and Causes of Bipolar Disorder in Children and Adolescents
This study is currently recruiting patients.
Sponsored by
Purpose
The purpose of this study is to learn more about and describe the moods and behaviors of children with bipolar disorder. This study will also examine what happens in the brain to produce these moods and behaviors. This is not a treatment study; children will not receive any new or experimental therapies
Children and adolescents ages 6 through 17 with bipolar disorder and normal healthy volunteers (controls) of the same age group may participate in this study. Candidates will have a telephone interview and review of medical records to determine eligibility. Additional screening will include a medical and psychiatric history of the patient and extended family members, and a physical and neurological evaluation. The medical history interviews will be videotaped and kept confidential.
Study participants will have a 3-day baseline evaluation, including the following physiologic tests and procedures:
1. Questionnaires and interviews about the subject's mood and behavior, stressful family events, and so forth, and observation and documentation of the subject's behavior twice daily by clinical staff.
2. Computer and written tests to assess intelligence, memory, learning, motor skills, reaction time, and planning skills.
3. Tests to measure heart rate, sweating, brain wave activity and eyeblinking while watching film clips that elicit various emotions and while playing computer games. Recordings include electromyogram, electrooculogram, heart rate, skin conductance, and electroencephalogram.
4. Needlestick to collect 3 tablespoons of blood to measure blood count and thyroid levels, liver and kidney function, to test the immune system and check for certain diseases, such as Lyme disease.
5. Magnetic resonance imaging (MRI) of the brain.
When the baseline evaluation is completed, the subject will return home for a 28-day period of "at-home observation." The subject and parent will complete daily questionnaires, and a NIMH staff member will observe the patient's behavior at home and at school for 2 days during this period. The observations will be videotaped and kept confidential.
At the end of the at-home observations, the subject and parent will return to the clinic for a 2-day evaluation that will include questionnaires, repeat physiologic tests described above, and a urine sample to check for drugs.
After this evaluation, control subjects will have completed their participation in the study. Follow-up evaluations will be scheduled for patients only as follows: at the end of 2 months, then every 3 months until a year has passed from the first visit, then every 6 months for 4 years. Some visits will involve only interviews and questionnaires, some will also include a physical exam, and urine test and others will also include a blood tests. A MRI brain scan will be done at 2 and 4 years.
Patients, their parents and siblings will also be asked to have blood drawn to obtain a DNA sample for genetic studies.
Condition - Bipolar Disorder
- Healthy
MEDLINEplus related topics: Bipolar Disorder
Study Type: Observational
Study Design: Natural HistoryOfficial Title: The Phenomenology and Neurophysiology of Affective Dysregulation in Children and Adolescents with Bipolar Disorder
Further Study Details:
Families who are interested in participating receive an extensive telephone interview and those who are judged to be likely to meet inclusion criteria are invited to the NIMH. There, study participants have a 5-day baseline evaluation, including physiologic tests and procedures, neuropsychological testing, and questionnaires and interviews about mood and behavior. In addition, staff members obtain a medical and psychiatric history of the patient and extended family members, and a physical and neurological evaluation. Participants are asked to perform computer and written tests to assess intelligence, memory, learning, motor skills, reaction time, and planning skills. Psychophysiological measures (such as heart rate, skin conductance, and electroencephalogram) are obtained in response to emotions and while playing computer games. Participants are asked to give blood samples for blood count and thyroid levels, liver and kidney function and to check for other diseases. Structural magnetic resonance imaging (MRI) scans of the brain are obtained.
After baseline evaluation, participants return home for a 28-day period of "at-home observation." Participants and parents complete brief daily questionnaires and participants wear an activity monitor on their wrist. Participants and parents then return to the NIH for repeat evaluations and physiologic tests after 2 months, and then every 3 months until 12 months have passed from the first visit. Thereafter, visits are every 6 months for 4 years. Some visits will involve only interviews and questionnaires, some will also include a physical exam, blood tests, and urine tests. Repeated MRI brain scan will be done at 2 and 4 years. Patients, their parents and siblings will also be asked to have blood drawn to obtain a DNA sample for genetic studies.
All tests and procedures are provided free of charge, and travel expenses are paid by the NIMH.
Genders Eligible for Study: Both
Accepts Healthy Volunteers
Criteria
- BIPOLAR PATIENTS:
- Boys and girls must be ages 6-17 and meet DSM-IV criteria for bipolar disorder.
- The child must have a primary caregiver who can accompany him or her on trips to NIMH, provide reliable history information, and complete daily rating scales and sleep logs.
- Patients must have a psychiatrist who provides clinical care for their Bipolar Disorder.
- All youth accepted into the study must be able to complete self-rating forms and to cooperate with other study procedures.
- Subjects must be on a stable medication regimen for at least 14 days prior to enrollment in the study. In addition, they, their parents, and treating physician must agree to keep medications stable (with the exception of minor dosage adjustments) until the end of the second NIMH evaluation, if clinically feasible and acceptable. The total duration of the medication-stable period will be approximately six weeks.
- Patients must have an I.Q. greater than or equal to 70.
- Patients must not have autistic disorder or severe pervasive developmental disorder.
- Patients must not have psychosis that interferes with the child's capacity to understand and comply with study procedures.
- Patients must not have an unstable medical illness (e.g., severe asthma).
- Patients must not have a medical illness that could cause the symptoms of bipolar illness (e.g., multiple sclerosis, thyroid disease).
- Patients must not be pregnant.
- Patients must not have engaged in substance abuse within two months of the initial evaluation.
- CONTROLS:
- Healthy normal volunteers.
- Control subjects will be age- and sex- matched to the patients.
- They will have normal physical and neurological examinations, and an identified primary care physician.
- Both control subjects and their first-degree relatives must be free of current or past psychopathology.
- Controls must have an I.Q. greater than or equal to 70.
- Controls must not have ongoing medical illness.
- Controls must not have neurologic disorder (including seizures).
- Controls must not be pregnant.
- Controls must not have engaged in past or present substance abuse.
- Controls must not have a history of sexual abuse.
Expected Total Enrollment: 400
- Maryland
- National Institute of Mental Health (NIMH), 9000 Rockville Pike, Bethesda, Maryland, 20892, United States; Recruiting
- Patient Recruitment and Public Liaison Office 1-800-411-1222 prpl@mail.cc.nih.gov
- TTY 1-866-411-1010
Publications
- Study ID Numbers 000198; 00-M-0198
- Study Start Date August 9, 2000
- Record last reviewed July 30, 2002
- Last Updated July 30, 2002
- NLM Identifier NCT00006177
- ClinicalTrials.gov processed this record on 2003-05-01
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