Bearing in mind that ceftriaxone is a meningitis drug
- a clue to the fact
that Lyme is a brain disease and not a knee disease -
Mark Klempner, in 1992, found that the reason ceftriaxone did not
kill all the Lyme spirochetes was that they were
Intracellularly, these spirochetes are
protected from the toxic effects of antibiotics. Alan Barbour reported that in
the presence of antibiotics, these spirochetes reverts to the cyst or spheroplast
form, which we all know to not be the end stage but rather a dormant or
The intracellularity of spirochetes has been well-known for
a hundred years.
dormancy is what characterizes these permanent spirochetal infections.
Klempner went with this stupid 4.7 million dollar study anyway, knowing
the reason ceftriaxone failed. We can tell from his conclusions
this "study" was conducted because that he/they intended not to allow us
to be treated with ceftriaxone regardless of the truth.
IV. The second most important study published by
Mark Klempner was the
matrix-metalloproteinase study where he found that 78% of
neuroborreliosis patients had
their spinal fluid, and he found that to be a SPECIFIC marker. That is, he
did not find this particular nerve and brain degrading enzyme in people with
other neurological disorders.
This is a pretty amazing
report because Klempner later said there was no evidence that Lyme causes
cognitive impairment, when his argument for studying MMP-130 was because of
the cognitive impairment in Lyme.
If the Lyme criminals claim "chronic bad-knee-Lyme" is an
autoimmune disease due to the hyperbinding of OspA to Steere's haplotypes, then
why shouldn't people imagine believe there isn't either a binding or a non-binding
autoimmune phenomenon going on in neurologic Lyme instead of saying such a thing
does not exist?
But, we're not saying chronic
neurologic Lyme is strictly an autoimmune disease, like Steere is saying
(fraudulently) that his kind of chronic Lyme is an autoimmune
disease. We're saying, A) there is more than one mechanism of autoimmunity
or immune dysregulation, so there does not have to be an either binding or
non-binding phenomenon going on; there could be other mechanisms [errant cloning of either B cells or T cells (pseudolymphoma), immune
suppression due to tolerance and down-regulation of HLA, disturbed pathways of
either HLAs or TLRs, disturbed signals from disturbed cytokine production, cytokines
acting as neurotransmitters, activation of latent viruses due to the inhibition
of the auto-kill kinases, downregulation of HLA, antibodies acting as neurotransmitters, etc.,...];
and B) persisting infection is not independent of autoimmunity, no matter what
kind of autoimmunity. It's not either/or. Chronic borreliosis is
definitely persisting infection, but it also could be autoimmune neurologic
disease. It is likeliest immune dysregulation process sets in combination
with persisting infection. The immune suppression outcomes of tolerization to
shed borrelial antigens renders people susceptible to opportunistic
infections and the exacerbation of latent viral and other infections of
all kinds which could be the cause of the New Great Imitator
outcomes. The immune suppression's resultant exacerbation of viral
and bacterial or mycoplasmal infections of all kinds could also be the
secondary causes of autoimmunity. The possible mechanisms of
illness are infinite. Instead of trying to discover why people are
sick for the benefit of revealing that information to others, this
information is being kept private by the cabal.
As we have seen
in the chapter on BIOMARKERS, the
suppression of the science, here, on immune suppression outcomes of Lyme
Disease and LYMErix, has negatively affected all other chronic and fatal
diseases. Their crimes are not just against people bitten by
QUI TAM and RICO-
Recover the money (temporarily suspend the reality where the government
no longer is about protecting the people):
One way to to stop the
tsunami of bovine excrement
from the Steere-CDC camp is to force them to retract all of their "bogus articles" and start over, particularly
with the moneys recovered by those who profited- and attempted to profit from- this spin, like the
insurance companies. So far, the Lyme crooks have not profited in the way they
intended since LYMErix was withdrawn, trashing their intended monopoly on
testing. But they have taken fraudulent income from the government,
so the individual prosecutions of the Lyme perps will come as separate,
individual Qui Tam fraud
cases. The crooks made false claims to the government in order to get more
funding to spin out more nonsense tales, like this, Klempner's 2001 "repeat
treatment," "study." Whenever they applied for a grant on
the basis of Dearborn being a reality, that is a false claim for grant
money. They clearly also made false claims on
behalf of BigInsurance, since Kaiser bailed out the financially failing
New York Medical College and they're still there at New York Medical
College, training MDs.
That happened at the same time as the establishment of the ALDF.com
which was right after the 1989 IDSA Review of Infectious Diseases, a
special publication about how serious Lyme is and that the
treatment endpoint was unknown. As stated in the
CRYME DISEASE introduction:
The Lyme crymes and the cabal -
The 180s - are
about an intended monopoly on vector borne diseases "test kits" and
"vaccines" and could not have happened without
the Bayh-Dole Act. The monopoly involved Kaiser-Permanente (still) at New
York Medical College and the deal was:
No one is allowed to have any
illness signs nor is treatment to be paid for, until the alleged "vaccine"
is ready, and then everyone will be notified about how serious that
particular vector borne disease is, and that they better get the
to be the agreement between the biotech patent profiteers and
Kaiser-Permanente at New York Medical College, which was in
financial trouble in 1990 under the leadership of John J. Connolly,
leading to the establishment of the false front non-profit called
the American Lyme
Disease Foundation Recall that when charging a RICO, one
does not have to prove the parties sat down together and made
deliberate statements and signed agreements about their intended
crime. There merely has to be the appearance that there was an
(4) “enterprise” includes any individual, partnership, corporation,
association, or other legal entity, and any union or group of
individuals associated in fact although not a legal entity;
This we can prove
due to the abundant statements made by the ALDF.com cabal about how
serious and dangerous Lyme Disease is when they wanted to sell their
"It is well known that Borrelia burgdorferi indeed after
asymptomatic infection can lurk or secrete itself in certain
areas of the body, perhaps the central nervous system or perhaps
the joint spaces, only to reappear months or maybe years later
in the form of late stages of illness which are harder to
diagnosis and treat.
"It is probably worth noting, since I have learned a lot,
that we don't have the clinical luxury in private practice that
we had in the SmithKline Beecham trial in which we had baseline
sera on all the patients who enrolled so that when they
presented with symptoms, we could draw acute and convalescent
serologies [recall that that was
the old diagnostic standard- see Chp 3] so as to
compare them with each other and with baseline to better
understand what symptoms they are presenting with.
Finally, there are indeed many dilemmas in therapy. In
particular, untreated or inadequately treated Lyme disease may
lead to the chronic morbidity with which we are very
familiar. Most commonly arthritis and the not common but
complex neurological syndromes are what often result and which
confront the primary care physician in the office diagnostically
These particular outcomes result in much more intensive,
long-term expensive therapy, often in the form of long-term
intravenous antibiotics. These are the patients who often are
refractory to treatment. Indeed, these are the patients in whom
symptoms seem to persist despite what we have given in terms of
adequate antibiotic therapy by any known measure.
In conclusion, we need a vaccine for Lyme disease because it
is increasing in incidence and geographic spread. We need a
vaccine for Lyme disease because there are problems in clinical
diagnosis, its laboratory evaluation, and its treatment. We
need a vaccine for Lyme disease because preventive measures are
unfortunately ineffective. Lyme disease is indeed vaccine
preventable. Availability of this vaccine would lead to a
significant reduction in chronic sequelae and substantive
morbidity. Lyme vaccine is thus a critical new public
health approach to the primary prevention of Lyme disease in the
United States. Thank you very much."-- Vijay
Sikand, EAST LYME, CT to the FDA Vaccine Committee in 1998
All in all,
original USDOJ July 2003 claim of "scientific fraud and racketeering" was correct.
I researched the crime and the laws thoroughly before filing the RICO
complaint with the USDOJ.
FRAUDULENT for Mark Klempner to use a check list to assess patient
outcomes when he knows there is a very specific marker in the CSF for
damage, and a rational person would wonder if the presence of this nerve
degrading enzyme was diminished with a month of ceftriaxone treatment.
'Not to mention that it is utterly crazy to try to sell a vaccine for a disease
against which Mark Klempner was at that very moment (Klempner's study
started in 1997) engaging in a bogus protocol intended to prove Lyme
disease- that terribly morbid chronic condition over which Vijay Sikand
begged the FDA Vaccine Committee to approve LYMErix - does not exist.
There is no question - thanks to Mark
Klempner - that we can validly claim that LYMErix was a placebo vaccine
against Lyme hysteria. It was the world's first ever placebo
vaccine and one that Yale said everyone in the country would need
every year. LYMErix was the first ever vaccine against catastrophizing.
And no one in the Connecticut, New
York or Massachusetts boards of health or medical boards said a
word. They STILL haven't said a word about this
placebo vaccine against hypochondria...
And the funny thing is, this cabal
intends to repeat the exact same ridiculous proposal:
You'd really have to be a world class jackass to propose that Lyme is
not dangerous while at the same time saying Lyme is so dangerous that we
need a vaccine against it. Here McSweegan says he needs a
hysteria-free trial of a new OspA vaccine -- which Mark Klempner says is
a placebo vaccine against hysteria because, Klempner said, Lyme is a
non-disease cured by "the placebo effect of antibiotics." We have
never seen a more insane set of American scientists continually get
their insanity published.
Ya see, because I am a real
scientist, which means I have no preconceived ideas about data.
I let the data tell me what to do, and not the other way
around. I am not a man and do not get all jerked off and whack my
pee-pee on my time off (nor post penis
data on the Lyme newsgroup, like Yale's Durland Fish), nor do I
pretend the whole world happens because of sex or
me or my pee-pee. If
anything, the absence of a penis is a godsend, because we women can
think so much more clearly than any of these self-alleged scientists or
MDs. Clearly Mr. Peanut is a major distraction even in the world
of vaccines. Yale's Steven Malawista literally declared that the
brain should be thrown out because it is "a complicating variable."
He really got that insanity published in a journal:
have largely limited the discussion here to Lyme arthritis, the
simplest case because the end point (no more arthritis) is so clear,
and one does not have to introduce complicating variables such as
the blood-brain barrier."
Malawista, Yale University
I wonder if castration would help in
more of the DSM disorders than the sex-OCD so common to psychiatrists?
Clearly McSweegan, Klempner and Malawista are out of their minds, but
remain free and unmedicated. They remain free and on the loose;
free to publish scientific insanity that is "dangerous and harmful to
others" in the medical journals. I have said many times that
Dante's Inferno needs to be updated to include a new
circle of hell for people who try to pass off such utterly crazy shit as
Yale is the anus mundi.
V. Dysimmunity and
the Other Secret Multiple Sclerosis Haplotype (HLA-DQB1*0602)
The following is the transcript
of what Mark Klempner secretly told the attendees of the Non-Diseases of Summer
Conference at South County Hospital in Rhode Island on approximately July 21,
2001 (it remains a secret, but blows away all of Klempner's conclusions):
"And, that is, that when you look for the possibility of
an autoimmune disease, the
way to look is to see if there is any genetic clustering in HLA haplotypes.
The reason for that is the way antigens get presented in the context of who
you are, that is, your HLA haplotype. And we can talk in some detail about
that. Those diseases that I think everybody would agree are so called
Autoimmune :lupus, rheumatoid arthritis, type 1 diabetes, and perhaps MS, have
some clear genetic clustering that leads us to believe that these are indeed
autoimmune diseases, although we do not satisfy so-called Koch’s Postulates of
autoimmune disease that we’ve written[?-KMD] about. And the odds ratio for
your having that particular HLA type, in the case of R.A, a DR4, or a DQB0602
to protect you from type 1 diabetes, are on the order of 3 to 6. One of the
ones that is probably
of course, is B27, in patients with alkyloiding spondolytis and the like.
turns out that if you look at the first 51 patients with post-treatment
chronic Lyme disease, the patient population that participated in our study,
there was a very high incidence of DQB0602 with an odds ratio of 770%.
So it may well be that exposure to THAT organism with THAT background of HLA
haplotype may lead you to develop chronic symptoms. That is a
that needs to be tested. It would obviously lead to an
new form and approach to therapy. "
Hear this very
big secret "not for large dissemination" "straight from the
horse's mouth." There were no questions by the MD-crowd at Rhode
Island's South County Hospital about this HLA secret. None of the
physicians questioned it. They just all pretended to understand
what Mark Klempner was talking about. I think pretending to know
what a medical scientist is talking about when you are an MD is a mental
disorder that should be added to the DSM-V.
Like, there was
no mystery to these Rhode Island MD morons when Mark
Klempner said there was no disease at all, but that he discovered this
autoimmune neurologic haplotype that they're supposed to "not largely
disseminate found at an 8 times higher rate than would be expected due
to chance in all these fricking Yuppie disease-wannabee whiners who
would otherwise have nothing to talk about cocktail parties and
Fibromyalgia is a women's disease related to the boredom associated with
low innate intelligence and a frustrated desire to be a soap opera
Not a one of
them said, "SO YOU FOUND SOMETHING WRONG WITH THESE PEOPLE, DR.
KLEMPNER???" They instead swooned and kissed his butt and
asked if he was a victim of us crazy Lyme victim terrorists. They
fed this bastard's ego instead of having a single independent thought
among the fifty or hundred or so of them. Rhode Island is a very,
very stupid and backward place. 'Even stupider than southeastern
Connecticut if that were possible.
In this report they say that the
chronic-knee people generally feel well, except for their arthritis
symptoms. This we suspected just from our limited experience with
such rare victims, and also due to a statement from Vijay Sikand at the
1998 LYMErix vaccine meeting where Sikand states that these arthritis
people could be considered "immune competent," or are able to make
enough antibodies to fight off infection. They say that this is a
blinded study and that:
First, we suspect that this is untrue
in that these criminals play a primers shell game, as previously
mentioned. Klempner never reported what DNA primers he used in this NEJM
nonsense report. Secondly, this supports the notion that it is the
immune suppression-exacerbation of latent common infections
(Epstein-Barr, Mycoplasma in the blood, Cytomegalovirus, etc.) caused by
chronic Lyme Disease and LYMErix vaccination, due to the tolerization of
fungal antigens (downregulation of HLA molecules) and the inhibition of
the auto-kill kinase mechanism induced by OspA as discussed in the
Biomarkers chapter (10).
Mark Klempner reported that OspA could cause cross reacting T cells to
neurologic tissues. He reported in 1998 that:
cells that react to OspA, OspC, and p22 epitopes also recognize MOBP, SST-R1,
and IL-R1, respectively, on neurons, possibly leading to encephalopathy and
radiculopathy. T cell recognition of synovial and neuronal proteins can
cause chronic symptoms for years after the initial infection. It is not
known whether the spirochete is still present during this chronic stage, or
whether symptoms are strictly due to T cell autoimmunity."
Klempner says here that OspA
(either from the bug or from vaccination) could cause an autoimmune disease of
the nervous system. This possibility (not fact) was never mentioned in this "chronic Lyme"
"study," yet clearly this report was published in 1998, when Klempner's "chronic
Lyme" "treatment" "study" was ongoing and clearly no new evidence emerged on persistence of
the infection. Klempner also reported in 2003 with a University of
Connecticut "ass ociate" (Kaplan) that there was no such thing as cognitive
impairment associated with "Lyme Disease."
[We agree that that's a
no-brainer, since there is no such thing as "Lyme Disease." "Lyme Disease"
is an imaginary self-limiting arthritis in a knee that needs no antibiotic
treatment, but it does apparently need a bogus vaccine.]
Klempner never reported this information about OspA vaccination possibly
being the cause of an autoimmune brain disease to the FDA, nor did he
say anything about it after the FDA approved LYMErix. The guy is the
All of this data,
including a complete dub, a tape, of this July 2001 Klempner lecture in
Rhode Island along with a transcript, was given to
the US Attorney in Connecticut who did nothing about it and then was promoted
twice in the USDOJ. CT Attorney General Richard Blumenthal and his staff
then had to take over the US Attorney's job for him without the federal pay and
the DOJ resources.
After committing the crimes of LYMErix and this
fake long term or repeat treatment "study," Klempner was promoted
to the head of
a CDC Level IV bioweapons lab in Boston. This should be seen as a criminal
endorsement, such as US Attorney
Kevin O'Connor of the District of Connecticut
being promoted to Alberto Gonzales' Chief of Staff, and then when Gonzales went
down, O'Connor was given the Number Three position at the United States
Department of Justice (sic).
Crooks in government are promoted and
whistleblowers get the bag job, since we're talking Republican whores, here,
which is the only kind of Republicans. Is the US not about to undergo a
bigger financial collapse than the Great Depression? Who outsourced us?
Who sold out our rights to the corporations?
About the likes of even the local
whores, like Cathy Cook (R-Mystic, CT) and Rob Simmons, former Republican
Congressman from Stonington, Corrupticut, we say "We grows da hoes big around
he-yuh,... since Pfizer is nearby and we use almost literally use Viagra as
fertilizer ta grow duh Republican hoes."
Repeat after me, class:
Klempner found that
spirochetes are intracellular and resistant to ceftriaxone.
Klempner found that Lyme
is a chronic infection that causes degradation of the central nervous system
The haplotypes data was not reported in Klempner's Long term
treatment report but a subsequent article by Wormser and Klempner
indicate an increasing likelihood that Chronic Neurologic Lyme is the
New Great Imitator due to the immune suppression-related exacerbation of
latent viral and acquired fungal infections of all kinds, rather than
neurologic autoimmunity, because, they say, there is no other haplotype
association to Lyme symptom outcomes except Steere's HLAs. Given the fact that OspA is the
source of the immune suppression, that alone could be the cause of the
cover up (vaccination with OspA and the cover up of the damages- the New
Great Imitator outcomes of LYMErix). While we once thought there
must be some association with Multiple Sclerosis haplotypes allegedly
secretly found in chronic neurologic Lyme and the tolerance to
Pam3Cys-related downregulation of the antigen-presenting cells (and the
subsequent cessation of antibodies to these antigens or the person
becomes "seronegative"), it now appears there was no association.
It could happen to anyone.
We knew about the immune dysregulation in 1992 from the NIH's, the NCI's
and the US Army's Paul Duray when he revealed the mutated lymphocytes
and stated that these looked like Epstein-Barr transformed cells.
None of this was pursued because scientific discovery could interfere
with the intended propaganda or marketing of LYMErix.
4) Mark Klempner suggested in
1998 that LYMErix could be causing an autoimmune neurologic disease but did
not report this to the public, ever, as a reason for concern or a reason to
Klempner was promoted by
the CDC to the head of a CDC Level IV bioweapons lab for his outrageous lies to and about the public.
VI. The following facts refute the validity of the
Klempner "long term" treatment "study," published in the New England Journal of
Malarkey on July 12, 2001:
A) The CDC positive "case definition" has never been proven to be accurate or valid for late,
treated Lyme, which were the patients Klempner claimed to be "studying." It was never proven to be a valid method to detect Lyme in the
first place. No one knows what, exactly, the Dearborn case "definition"
criteria means, since no one agreed with the Steere IgG proposal at the 1994 CDC
Dearborn, MI, self-alleged conference, self-alleged to be about "Standardization
of Western Blotting." Steere
never validated his IgG Dressler/Steere method according to the FDA rules for
the validation of an bioanalytical method. The participants in the Dearborn
conference said Steere's IgG proposal was 8-28% accurate when tested in the
When Steere tested his own proposal in the
field, he found that 39 of 54 arthritis patients were positive to his IgG panel proposal
of 18, 23 (OspA), 28 (porin), 30, 39 (flagellar sheath), 41 (flagellin),
45 (porin), 58, 66 (porin), 93 (Could be 31 times three, or it could be the
specific brain invasion antigen that the Europeans claim). We actually have no idea what Steere observed, since he obtained this
"data" with bogus, NIH- and CDC- NOT-recommended strains from
Guilford, CT, Germany and Russia, and to boot, they were all "HIGH PASSAGE"
(strains FRG and high passage G39/40). Since we don't know what
"Dearborn positive" means in previously treated patients, we have no idea
what kind of patients Mark Klempner had. Even the participants of the
CDC's bogus Dearborn conference,
(Phil Molloy) said ~ "We have no idea what Dearborn means." Therefore, the only real
result Mark Klempner had from this "study," was that 78 out of 1800 patients
tested Dearborn positive after some antibiotic treatment (accuracy of
Dearborn Lyme is 4% in treated patients).
Klempner's "study" was supposed to be a "repeat treatment" "study" of
previously treated Lyme victims, when most (2/3rds) had never had
previous IV ceftriaxone treatment. He already knew the reason ceftriaxone
failed to cure. At the time of the proposal of the Klempner study
protocol, the standard of care was 30 days of intravenous ceftriaxone- which was
an arbitrary determination in the first place. The standard of care was 30
days of intravenous antibiotics at the time of the Klempner "study," since
that's the standard mode of delivery of antibiotics for brain infections or
meningitis and was in use for years.
Thus, Klempner's "long term re-treatment study," was a "standard of care study,"
and it showed that 30 days of the IV drug used for bacterial infections of the
brain or meningitis was not enough intravenous antibiotics and that the
chronically fatigued, neurologically and cognitively impaired victims of
Klempner and Lyme should have been given at least 2 months of ceftriaxone.
It was always known that borrelioses
are permanent brain infections and Relapsing Fever. Therefore we would
expect that Lyme should be treated as a Relapsing Fever brain infection, and
that the treatment of its victims should be relapsing IV ceftriaxone. No
one says these things because they are logical. What
we know now from the Fallon study is that one should start with at least
3.5 months of intravenous ceftriaxone and if patients relapse after
that, perhaps add another month. And if they relapse after that,
repeat. Somewhere along the line it became acceptable to tell
people it's okay if they remain chronically miserable, when the same
people know of a treatment that brought relief (Dattwyler
Amazingly, these bizarro facts have never, ever once made it into any
media, much less main stream media. The MDs don't ask any
questions and the newspapers have forgotten the part about investigating
unanswered questions. The media and the AMA and the DOJ totally
accept hypocrisy to the point where they're convinced they're the
guardians of the corporations rather than the people. I feel like I'm
watching that black kid in Florida DCF pediatric prison being beaten to
death by several prison guards for being a juvenile thug on a national
scale. This country is so screwed up and the victims are so
routinely tortured and we're so used to it, that the next thing we can
expect is a new wave of New Roman Coliseum Theatres moving back into the
towns with the lions and the blood and guts and gore as a new way to
treat sick people... and then we'd have to listen to the animal rights
people crusading over the poor lions' diet.
Klempner threw out PCR positive patients and then lied about it.
Klempner reported that no PCR-positive patients were included in his study.
He stated right in the full text NEJM article that he did not accept PCR
positive victims in his study.
There were PCR positive Klempner victims who were excluded from the "study"
because they were positive and this is known to the Lyme community since these
rejectees are part of the Chronic Lyme community.
In the audiotape of
Mark Klempner at the
South County Non-Diseases of Summer Conference in July 2001, Klempner said that
out of 2000 patients, none were DNA positive for the Bb DNA in their spinal
fluid. Klempner is a liar.
Mark Klempner never published what primers he used to determine "DNA
the spinal fluid of his victims. As we have seen in previous chapters, one
must use genus-specific primers such as multiple Borrelial (from several of the
genera) flagellins and intragenic
spacers (RNA) that identify Relapsing Fevers (or Borreliae). Klempner claims to have used a culture method when we
all know and knew culture is inferior to DNA/RNA testing or the
asked directly to reveal what primers he used, Mark Klempner refused to reply.
According to IDSA's Russell Johnson, it "could take months" to recover
intact spirochetes from the spheroplast form in BSK media. Klempner
only attempted to reculture spheroplasts from spinal fluid for 3 weeks.
Mark Klempner while saying he looked for other vector-borne infectious
diseases, he did not look for the activation of latent viral infections-
which have become activated due to the immune suppression of Lyme, like
HHV, Epstein-Barr, measles, etc, which have previously been associated
No Scientifically Valid Tests Used to Assess Outcomes, and then he
claimed hysteria to be the cause of the illness. Klempner even
claimed that people who got better from treatment were reporting merely
"a placebo response to antibiotics."
The Fibromyalgia Impact Questionaire (FIQ) was invalidated rather than validated for
use in Lyme victims. Arthur Weinstein has
proposed method validations in the past which are not validations. In the
case of the FIQ, he found that Fibromyalgia and Lyme disease were two different
diseases. If they are two different diseases, the test or the method
itself is not valid, since a validation requires that the test is SPECIFIC to
the analyte in question.
The second most glaringly
ridiculous aspect of the Klempner study next to the ceftriaxone failure is that he never used any of the
scientifically valid markers of illness identified by IDSA, when we himself knew there were
at least matrix-metalloproteinases in the spinal fluid of most of his
seronegative Lyme victims, GFAp and
quinolinic acid in the spinal fluid which shows chronic meningitis resulting in
the degradation of the central nervous system, autoantibodies to nerve tissue,
dysregulated cytokines, brain evoked potentials slowing (QEEG), gadolinium contrast MRIs of monkey Lyme brains show chronic meningitis, and
that Lyme results in ALS and MS.
things, and he was clearly
aware of the parallel study going on at the NINDS where Roland Martin was
treating MS-Lyme patients with both antibiotics and MS medicines. Klempner is the
author of the studies where ceftriaxone failed and of the discovery of the MMPs in
the spinal fluid of neuroborreliosis patients.
That Klempner would dare to
suggest that Lyme victims are responding to the antibiotics due to the "placebo
effect" is a sure sign that Klempner thinks all MDs are morons, and he would be
right, since none of your authors has an MD degree, yet this is simple science.
Klempner's history is obvious to a person with the curiosity of a 7 year old.
The Nutcase Anthony Fauci
Now recall that
in the summer of 2003 Anthony Fauci lied his face off on the CNN Lou
Dobbs show about the LYMErix vaccine. He said on the show the
exact opposite of what I told the FDA Vaccine Committee which was that
LYMErix was not a scientifically valid vaccine because Yale did not use
a scientifically valid test to assess for its efficacy. The
Dearborn method misses 85% of the cases according to the Infectious
Diseases Society's Gary Wormser. Said The Fauc' to Lou Dobbs:
an effective vaccine, but it's the kind of vaccine that you have to
essentially vaccinate people each year. And from the standpoint of
it's use, it has not been used as efficiently as it could have been
used. So scientifically, we had a vaccine and still do have a
vaccine, but it's not really well used."
Note that the
summer of 2003 was over a year after LYMErix had been withdrawn from the
market. Note also that the Dearborn standard only allows for the
inflammatory kind of Lyme disease to be recognized, diagnosed and
treated (granted that Malawista in his article where he recommended that
the brain be thrown out said that Lyme arthritis should not be treated
either because it goes away on its own in 4 years). Note also that
in a PBS interview for their "Life on Earth" series, Yale's Eugene
SHAPIRO: What some people would have you believe is that
there are two different diseases.
SHAPIRO: Somehow, for that form of the disease,
antibiotics are effective. They do fine. But then there's
some other form of the disease which is, you can't put your hand
around it. They don't have objective findings of inflammation,
which is the way bacteria cause disease.
So, there is
Anthony Fauci, the head of NIAID, agreeing with the Lyme criminals that
the only way a person could have a disease is if they have inflammation.
Of course in the previous chapter, we proved that the immune suppression
outcomes of Lyme disease due to tolerization to such fungal antigens as
LYMErix and the HIV antigens gp120 and gp41 are likely to be the cause
of all the New Great Imitator Neurological outcomes, such as Multiple
Sclerosis, ALS, and the like, through immune suppression, the anchoring
of the auto-kill kinases and the activation of latent viral and
infections and allowing for all kinds of opportunistic infections, such
as mycoplasmal infections in the blood.
Amazingly, if one
searches the patent database, one would find a Fauci patent for the
treatment of immune suppression outcomes of bacterial, viral, and fungal
FIELD OF THE INVENTION
The present invention pertains to a method for activating the immune
system of a patient by intermittently administering interleukin-2 (IL-2)
to that patient. Such administration of IL-2 can optionally be combined
with other therapies, such as anti-retroviral, anti-bacterial or
anti-fungal therapies, suitable for treatment of the patient's
condition. This invention also relates to an approach to gene therapy
that entails administering IL-2 to a patient so as to facilitate in situ
lymphocyte transduction by a retroviral vector also administered to the
BACKGROUND OF THE INVENTION
Attempts at immune activation and restoration in the past have utilized
bone marrow transplantation or lymphocyte transfers (H. C. Lane et al.,
Ann. Internal Med. 113:512-19 (1990)), immunomodulating agents such as
immuthiol (J. M. Lang et al., Lancet 24:702-06 (1988)) or isoprinosine
(C. Pedersen et al., N. Engl. J. Med. 322: 1757-63 (1990)), and
recombinant cytokines such as interferon alpha (IFN-.alpha.) and IL-2.
H. C. Lane et al., Ann. Intern. Med. 112:805-11 (1990); H. C. Lane et
al., J. Biol. Response Mod. 3, 512-16 (1984); D. H. Schwartz et al., J.
Acquir. Immune Defic. Syndr. 4, 11-23 (1991); P. Mazza et al., Eur. J.
Haematol. 49:1-6 (1992); H. W. Murray et al., Am. J. Med. 93:234 (1992);
H. Teppler et al., J. Infect. Dis. 167:291-98 (1993); P. Volberding et
al., AIDS Res. Hum. Retroviruses 3:115-24 (1987). These studies have
resulted in minimal or only transient immune system restoration.
The use of biologic response modifiers in general, and of IL-2 in
particular, is an active area of clinical research. Interleukin-2 is a T
cell-derived lymphokine with a number of immunomodulating effects
including activation, as well as induction of proliferation and
differentiation, of both T and B lymphocytes. K. A. Smith, Science
140:1169-76 (1988). Exogenous IL-2 has been shown in vitro to increase
the depressed natural killer cell activity and cytomegalovirus-specific
cytotoxicity of peripheral blood mononuclear cells from patients with
AIDS, as well as to increase IFN-.lambda. production by lymphocytes from
patients with AIDS. A. H. Rook et al., J. Clin. Invest. 72:398-403
(1983); H. W. Murray et al., loc. cit. 76:1959-64 (1985).
It's a patented treatment for the immune suppression outcomes of Lyme
disease, which is a condition simultaneously denied by the head of the
National Institute of Allergy and Infectious Diseases- who owns this
"It is an indescribable experience knowing that what you are doing
will have an impact on the lives… of millions of people." —Anthony Fauci,
Ton'. It's been fabulous.