UPDATED PAGE: BRAIN_PERMANENT.htm
Item 22 below is the one with the oral treponemes and Alzheimer's.
IDSA REVIEWS 1989
"Treatment fails in half the neurologic cases,"
say Dattwyler, Luft, Sigal and Steere.
1) "The ability of the borrelia, especially tick-borne strains to persist in the brain and in the eye after treatment with arsenic or with penicillin or even after apparent cure is well known (1). The persistence of treponemes after treatment of syphilis is a major area which currently requires additional study (3,5,10,11). -Jay Sanford, US Military Hospital, Bethesda, MD
(this textbook was edited by Russell Johnson who was a member of the board of the ALDF.com)
2) "The propensity for borrelia to go to the brain of infected mammals suggests that the relationship between these spirochetes and neural tissues is not trivial. Further study of this attraction and the interaction that follows may reveal the basis for the significant nerve and brain involvement in Lyme borreliosis"-- Alan Barbour
'Storing spirochetes in rodent brains, Alan Barbour
3) "The chronic forms of the disease such as arthritis (joint involvement), acrodermatitis chronica atrophicans (skin involvement), and Bannwart's syndrome (neurological involvement) may last for months to years and are associated with the persistence of the spirochete. A case of maternal-fetal transmission of B. burgdorferi resulting in neonatal death has been reported. Domestic animals such as the dog also develop arthritis and lameness to this tick-borne infection. For every symptomatic infection, there is at least one asymptomatic infection. Lyme disease is presently the most commonly reported tick-borne disease in the United States." -- Russell Johnson, in the first patent for a Lyme vaccine
The patent also says:
4) "We are taking a multi-discipline approach, including methods of genetics, cell biology, and immunology, to study in depth two spirochetal diseases: Lyme disease and relapsing fever. These tick-borne infections are notable for multiphasic antigenic variation through DNA recombinations in the case of relapsing fever, the occurrence of chronic arthritis in the case of Lyme disease, and invasion of and persistence in the brain in the case of both diseases. ---Alan Barbour
5) Allen Steere says: http://www.annals.org/cgi/content/full/121/8/560 "Patient 12 had had high fever, meningeal symptoms, and subsequent arthritis in 1982. She was noted to have a positive serologic test result for Lyme disease 4 years later and was treated with 2 weeks of parenteral penicillin. She later developed a progressive speech disorder, bradykinesia, and abnormal ocular motor function. Magnetic resonance imaging of the brain showed scattered white matter lesions in the hemispheres and pons, and she was diagnosed with supranuclear palsy. Lumbar puncture showed no selective concentration of antibody in the spinal fluid. Nevertheless, she was re-treated with 2 weeks of parenteral ceftriaxone in 1989 that had no effect on her neurologic symptoms. During the time of observation, this patient died. At autopsy, lymphoid mononuclear cells were observed surrounding the intracerebral vessels in one section. Using Dieterle silver stain, a spirochete was present in the cortex and another was exterior to a leptomeningeal vessel."
(One of Steere's multiply treated patients died anyway with spirochetes in her brain.)
6, 7) Steere and Nocton (2 articles, both showing persisting infection past treatment, even using the wrong DNA or RNA primers)
In the following report, Steere found persisting DNA in joints for up to ten years, after treatment, even using the wrong primers.
Mark Klempner says: "Fibroblasts protected B. burgdorferi for at least 14 days of exposure to ceftriaxone. Mouse keratinocytes, HEp-2 cells, and Vero cells but not Caco-2 cells showed the same protective effect. Thus, several eukaryotic cell types provide the Lyme disease spirochete with a protective environment contributing to its long-term survival." HERE on Medline (same report as above)
10) Klempner reports that OspA or LYMErix could be a brain toxin as if that needs an explainer.
11) Yale Pathology and the Congenital Brain Infection of Newborn Resulting in Death "The death of the newborn was probably due to respiratory failure as a consequence of perinatal brain damage."--
12) "US Attorney" O'Connor and Schoen's Brain Destruction Report Note the content of the GFAp reference cited by Yale's Robert Schoen when trying to sell a Lyme vaccine. Within 3 weeks after infection, there is evidence of gliosis or destruction of glial cells in the central nervous system. This is somewhat inconsistent with Schoen's simultaneous assertion that we have "Lyme Paranoia" and not a real disease, especially since no one believes us that we're sick, so why should anyone believe the sickness is caused by anxiety and not illness?
13) CDC participates in (Liegner) autopsy and identifies persisting DNA in samples of patients treated many times for Lyme, which therefore proves antibiotic treatment does not completely eradicate the Lyme infection.
14) "...the specter of asymptomatic infection is something that troubles me a great deal and troubles a great number of my colleagues who need to treat Lyme disease. The obvious analogy with syphilis infection with Treponema pallidum is there to consider. It is well known that Borrelia burgdorferi indeed after asymptomatic infection can lurk or secrete itself in certain areas of the body, perhaps the central nervous system or perhaps the joint spaces, only to reappear months or maybe years later in the form of late stages of illness which are harder to diagnosis and treat." ---Vijay Sikand
15) The combined national institutes say: --http://intramural.nimh.nih.gov/inip/call4proposals.htm "8. Infectious diseases of the CNS mediated through immune mechanisms, including acute and chronic Lyme disease and neuroAIDS;"
16) Early Brain Invasion by Lyme crook, Benach. Benach later sent a letter to the editor of the New York Times stating that Allen Steere was right, that we Lyme victims are delusional, and that "Allen Steere has the science on his side," when you can clearly see that we have Jorge Benach's science as well as Allen Steere's on our side.
17) Early Brain Invasion by Ray Dattwyler- author of the IDSA "guidelines" as told to the FDA in 1994.
18) Pachner_Brains_1990 Antigenic variation in the brain. This means you can't use the Dressler-Steere antibody method to determine late Lyme in the brain.
19) IDSA REVIEWS 1989 "Brain Parenchyma involved-" Pachner
20) John Dunn at Brookhaven says that It's "the perfect stealth pathogen" that can mistaken for MS, Lupus, can cause excruciating headaches.
'Storing Spirochetes in rodent brains, Oscar Felsenfeld: Don't use mouse brains to prove persisting infection in humans, since the mice aren't the best brain reservoirs (hamsters are apparently better human brain-infected models, which is why they're not used by the crooks any more)
21) Alan Barbour on what happens if you wait long than 7 days to treat Lyme very aggressively:
Antimicrob Agents Chemother. 1996 Nov;40(11):2632-6
In vivo activities of ceftriaxone and vancomycin against Borrelia spp. in the mouse brain and other sites.
Department of Medicine (Infectious Diseases), University of Texas Health Science Center at San Antonio 78284, USA.
Borrelia burgdorferi, the agent of Lyme disease, and B. turicatae, a neurotropic agent of relapsing fever, are susceptible to vancomycin in vitro, with an MIC of 0.5 microgram/ml. To determine the activity of vancomycin in vivo, particularly in the brain, we infected adult immunocompetent BALB/c and immunodeficient CB-17 scid mice with B. burgdorferi or B. turicatae. The mice were then treated with vancomycin, ceftriaxone as a positive control, or normal saline as a negative control. The effectiveness of treatment was assessed by cultures of blood and brain and other tissues. Ceftriaxone at a dose of 25 mg/kg of body weight administered every 12 h for 7 to 10 days eliminated cultivable B. burgdorferi or B. turicatae from all BALB/c or scid mice in the study. Vancomycin at 30 mg/kg administered every 12 h was effective in eliminating infection from immunodeficient mice if treatment was started within 3 days of the onset of infection. If treatment with vancomycin was delayed for 7 days or more, vancomycin failed to eradicate infection with B. burgdorferi or B. turicatae from immunodeficient mice. The failure of vancomycin in eradicating established infections in immunodeficient mice was associated with the persistence of viable spirochetes in the brain during antibiotic treatment. PMID: 8913478 [PubMed - indexed for MEDLINE]
22) Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer's disease.
http://www.ncbi.nlm.nih.gov...11929559 medline link to verify
Department of Pediatric Dentistry, School of Dentistry, Oregon Health and Sciences University, Portland, OR 97201-3097, USA.
The purpose of this investigation was to use molecular and immunological techniques to determine whether oral Treponema infected the human brain. Pieces of frontal lobe cortex from 34 subjects were analyzed with species-specific PCR and monoclonal antibodies. PCR detected Treponema in 14/16 Alzheimer's disease (AD) and 4/18 non-AD donors (P < 0.001), and AD specimens had more Treponema species than controls (P < 0.001). PCR also detected Treponema in trigeminal ganglia from three AD and two control donors. Cortex from 15/16 AD subjects and 6/18 controls contained Treponema pectinovorum and/or Treponema socranskii species-specific antigens (P < 0.01). T. pectinovorum and/or T. socranskii antigens were also found in trigeminal ganglia and pons from four embalmed cadavers, and 2/4 cadavers also had Treponema in the hippocampus. These findings suggest that oral Treponema may infect the brain via branches of the trigeminal nerve.
PMID: 11929559 [PubMed - indexed for MEDLINE]
This is IDSA's own data on Lyme borreliosis as a permanent brain infection. (I hope they don't forget to turn it all over to AG Richard Blumenthal in his antitrust investigation, because then, that would be an additional crime.)
This data (still building this page as of 28 July, AM) you will find nowhere else in the same place in the entire universe, and more importantly, not a single MD in America even cares to attempt to do the same. They feel no obligation to right wrongs, yet they take an oath to First Do No Harm?
Even more interesting is this KOOK of a psychiatrist who published that "there will be no more spirochete-like discoveries," yet within a year or two a woman scientist at Yale determined that prion diseases could be due to a slow virus (just google Yale Virus Prion), and the world has come to understand that Toxoplasmosis effects fetuses. Yet a third astounding fact, is that MANY of these tick borne diseases make their homes in the brain including babesia and erhlichia. A fourth astounding fact is that dentists have determined that the majority of Alzheimer's disease cases have oral spirochetes in their brains, and that these spirochetes travel along inside nerves, as was determined to be the case with syphilis spirochetes.
And yet a fifth astounding fact is that we learned that Multiple Sclerosis may be chronic neuroLeptospirosis:
Note- Who bothers to look into these matters? Not anyone at the American Medical Association (JAMA), since, What do they care about suffering? They only care about money. They only sued BigInsurance over inadequate payments to themselves in a class action and not Kaiser's interference with educating MDs at New York Medical College, or at the AHRQ.gov or the Institute of Medicine or anywhere else.
AMA NEVER has advocated for the care of people who suffer, in any court.