Dr. Ranger                                                                                                       12 May 06

Pond Ward

Center for Mental Health                                                                      http://actionlyme.org

Central Way

London

NW10-7WS

CC: The Embassies of China and Russia in the United States

The US Department of Justice, Office of Special Counsel

United States Attorney General, Alberto Gonzales

Senators Reid, Schumer, Kerry, Kennedy, Grassley, Enzi, Frist

President of the United States

Connecticut Attorney General Richard Blumenthal

New York Attorney General Eliot Spitzer

United Nations Human Rights Commission, Geneva

The Lyme Disease Foundation (www.Lyme.org)

The Washington Post

Regarding Lisa Masterson, victim of harassment and abuse because her children have Lyme disease.

Excuse me for being stupid, but doesn’t the obvious fact that Lisa was bagged by you kooks validate her complaint that she was being stalked?

I have enclosed some of the evidence of who was trying to hack into my computer, too.

Now how would I know the British Social Security was hacking me, unless I had their IP number, which I got through my ZoneAlarm hacking stopper software?

Simon Wessely is a low life, does nothing valid, harassed the Gulf War Illness victims with his psychiatric MumboJumbo, and that was after Lyme/ME patients were bagged by the other famous UK psychiatric nutcase, Roy Meadows.

Let me tell you something, you psychiatric lunatics who know nothing about VALID SCIENCE, Lyme borreliosis is a borreliosis, which is a stealth pathogen. The only antibody markers for it are flagellin, or band 41- the very same band that the Lyme crooks say is meaningless. Yale validated the accuracy of this method in 1991, and patented it in 1993.

A huge FRAUD was committed here, and you psychiatric nutcases in the UK, and here at Yale University, would not know a brain from an artichoke.

I recommend my videos for your education, because the SCIENCE and the data is referenced, and I filed a scientific FRAUD and racketeering complaint to the US Department of Justice 2.5 years ago, and they STILL have done nothing, because the DOJ was hijacked by the NeoCons- Witness Alberto “TORTURE IS GOOD” Gonzales.

This entire country is in an uproar over the BushCo and Blairites and I understand the British people want Tony the NeoCon brown noser to take a hike as soon as possible.

Simon Wessely, let me tell you, is an arrogant son of a bitch, and he did an essay on “PRIDE” for the BMJ. In that essay, he pats himself on the back for being a moron. “The one thing about me is that I am smart and I know it, so I should have pride.”—Love to me, Simon Wessley.

He is SICKENING.

No one cares where he lives. Apparently he told everyone where he lives at his last FRAUD meeting where he brought his son, to which the Lyme activists responded, “Well, either he really is not in fear of his life, as he claims, or he intends to use his own son as a shield.”

LISA AND I WERE LAUGHING OUR ASSES OFF OVER THIS THE DAY BEFORE SHE WAS KIDNAPPED BY YOU STINKING IGNORANT BRITISH PSYCHIATRIC MORONS.

Let Lisa go and give her her kids back. The only threat to you is that she makes complete jackasses out of you, which was not hard to do, and you have proven that you are jackasses by abusing her further for knowing the truth about the FRAUD in the testing for borreliosis.

You are stupid and cowardly folk, you psychiatric nitwits. If you have the evidence, or have been given an opportunity to look at the evidence, that Lisa has indeed been stalked and harassed, you are a disgrace to humanity to keep her locked up.

The Gulf War Illness victims had their day of vindication via Seymour Hersch and The New Yorker magazine. Mr. Hersch just exposed the US Morons in the White House as regards their Iran nuking intentions. Today we learned the US President is a liar. Again. Ho hum. What will tomorrow’s news be? The President is a liar?

I’d like you to know we are watching this, and we’re tired of the abuse, and we know that borreliosis is a bioweapons because we learned that fact from none other than Edward McSweegan- the very guy who stalked and harassed both Lisa and I. You know, McSweegan “Hung like a horse” McSweegan. Referencing the last fax I sent you on this nutcase.

Before McSweegan harassed and stalked myself and Lisa, he did the same thing to Karen Forschner of the Lyme Foundation. McSweegan was accused and sued in a lawsuit specifically for STALKING the Forschners.

You see, the big deal is, chronic Lyme suppresses the immune system so that there are no antibody markers to the fungal type lipoproteins. You know, like mycoplasma and Gulf War Illness. You know, like the mycoplasmas we sold Iraq to use against Iran. You know, the reason BushCo Senior did not finish off Saddam in 1991. He knew about the bioweapons there because we sold them to them. This was not denied by the Plum Island Director- who was a woman at the time – when confronted with the evidence in Guilford, CT.

Chronic fungal stealth infections. You know, like Gulf War, Chronic Fatigue Syndrome, Lyme borreliosis, Myalgic Encephalitis. It’s all the same basic illness and do you know how we know?

For the doubters, Lyme and LYMErix cause the same immune suppression that mycobacteria and mycoplasma cause:

"Lipoproteins and lipopeptides have been identified in a large number of microorganisms, the most prominent ones being mycobacteria, mycoplasms, and spirochetes. They have been found to exhibit both a strong innate inflammatory response in the host and an enduring adaptive immune response in mammalian hosts (16). The strong proinflammatory capacities of lipoproteins were first described for outer surface proteins A and B of Borrelia burgdorferi, which are also highly immunogenic (17) and have lately been the basis for a Lyme disease vaccine development (18). These compounds exhibit an triacylated lipid anchor structure comprising an N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteinyl (Pam₃Cys) moiety at the N terminus (19), a feature that was previously described for the Braun lipoprotein from Escherichia coli (20). Because the N-terminal Pam₃Cys modification is essential for immunoactivation caused by lipoproteins of B. burgdorferi as well as of another spirochete, Treponema pallidum (21), subsequent studies investigating immune responses to spirochetes used synthetic lipopeptides (22). The Pam₃Cys moiety was also reported to be present in cytokine-inducing lipoproteins of Mycobacterium and Mycoplasma spp. (23, 24); thus, it can be regarded as a highly conserved molecular motif among different classes of bacteria. In Mycoplasma fermentans, the presence of a macrophage stimulating lipopeptide, termed 2-kDa macrophage-activating lipopeptide (MALP-2), was observed, being stimulatory active at picomolar concentrations (25). This compound, in contrast to the predominant lipopeptide structures present in lipoproteins of E. coli, B. burgdorferi, and mycobacteria, lacks the N-palmitoyl group, thus containing a diacylated (Pam₂Cys) lipid anchor structure at the N terminus. Following studies revealed the presence of closely related compounds in other Mycoplasma spp. (26).."    from:      http://www.jimmunol.org/cgi/content/full/173/4/2683

How LYMErix caused illness- immune suppression:

"Signaling through TLR-2 by lipoproteins may represent a double-edged sword for host responses to chronic intracellular pathogens such as M. tuberculosis. Short-term signaling through TLR-2 activates macrophages and initiates acute inflammation that may help control initial infection. In contrast, prolonged TLR-2 signaling in macrophages results in down-regulation of certain critical immune functions, such as MHC-II Ag processing. M. tuberculosis infects, survives, and persists in macrophages. The ability of M. tuberculosis to survive acute inflammation positions the bacilli to take advantage, through secretion of lipoproteins such as LprG and LpqH, of this down-regulation of macrophage immune function." 

http://www.jimmunol.org/cgi/content/full/173/4/2660 The Journal of Immunology, 2004, 173: 2660-2668.    Copyright © 2004 by The American Association of Immunologists Mycobacterium tuberculosis LprG (Rv1411c): A Novel TLR-2 Ligand That Inhibits Human Macrophage Class II MHC Antigen Processing¹ Adam J. Gehring^*, Karen M. Dobos, John T. Belisle, Clifford V. Harding^2, and W. Henry Boom^{2,3,*,, *} Division of Infectious Diseases, Department of Pathology, and Tuberculosis Research Unit, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106; and Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523

More on this type of immune suppression from MedLine

Must read:  http://www.jbc.org/cgi/content/full/274/47/33419  (UCONN's Justin Radolf)

"Toll-like receptors (TLRs) 2 and 4 are signal transducers for lipopolysaccharide, the major proinflammatory constituent in the outer membrane of Gram-negative bacteria. We observed that membrane lipoproteins/lipopeptides from Borrelia burgdorferi, Treponema pallidum, and Mycoplasma fermentans activated cells heterologously expressing TLR2 but not those expressing TLR1 or TLR4. These TLR2-expressing cells were also stimulated by living motile B. burgdorferi, suggesting that TLR2 recognition of lipoproteins is relevant to natural Borrelia infection. Importantly, a TLR2 antibody inhibited bacterial lipoprotein/lipopeptide-induced tumor necrosis factor release from human peripheral blood mononuclear cells, and TLR2-null Chinese hamster macrophages were insensitive to lipoprotein/lipopeptide challenge. The data suggest a role for the native protein in cellular activation by these ligands. In addition, TLR2-dependent responses were seen using whole Mycobacterium avium and Staphylococcus aureus, demonstrating that this receptor can function as a signal transducer for a wide spectrum of bacterial products. We conclude that diverse pathogens activate cells through TLR2 and propose that this molecule is a central pattern recognition receptor in host immune responses to microbial invasion."   http://www.jimmunol.org/cgi/content/full/173/4/2683

=========

Borrelia burgdorferi Lipoprotein-Mediated TLR2 Stimulation Causes the Down-Regulation of TLR5 in Human Monocytes.

Cabral ES, Gelderblom H, Hornung RL, Munson PJ, Martin R, Marques AR.

Clinical Studies Unit, Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Toll-like receptors (TLRs) trigger innate immune responses via the recognition of conserved pathogen-associated molecular patterns. Lipoproteins from Borrelia burgdorferi, the agent of Lyme disease, activate inflammatory cells through TLR2 and TLR1. We show that stimulation of human monocytes with B. burgdorferi lysate, lipidated outer surface protein A, and triacylated lipopeptide Pam(3)CysSerLys(4) results in the up-regulation of both TLR2 and TLR1 but the down-regulation of TLR5, the receptor for bacterial flagellin, and that this effect is mediated via TLR2. TLR4 stimulation had no effect on TLR2, TLR1, and TLR5 expression. Human monocytes stimulated with TLR5 ligands (including p37 or flaA, the minor protein from B. burgdorferi flagella) up-regulated TLR5. In addition, TLR2 stimulation rendered cells hyporesponsive to a TLR5 agonist. These results indicate that diverse stimuli can cause differential TLR expression, and we hypothesize that these changes may be useful for either the pathogen and/or the host.
PMID: 16479520 [PubMed - in process]

BECAUSE IT IS PUBLISHED.

1: Microbes Infect. 2002 Sep;4(11):1133-40.

Related Articles, Links

·
The immune response to infection with Treponema pallidum, the stealth pathogen.

Salazar JC, Hazlett KR, Radolf JD.

Center for Microbial Pathogenesis, MC 3710, University of Connecticut Medical School, 263 Farmington Avenue, Farmington, CT 06030, USA. jsalaza@ccmckids.org

Cutaneous immunobiology and spirochetal molecular biology have allowed investigators to propose a conceptual framework for the development of both the innate and adaptive immune response to Treponema pallidum infection. While some clinical manifestations can be attributed to humoral responses, most can be attributed to a combination of local innate and adaptive cellular immunity.
PMID: 12361913 [PubMed - indexed for MEDLINE]

1: Rev Infect Dis. 1989 Sep-Oct;11 Suppl 6:S1482-6.

Related Articles, Links

Neurologic manifestations of Lyme disease, the new "great imitator".

Pachner AR.

Department of Neurology, University Hospital, Georgetown University Medical School, Washington, D.C. 20007.

The causative agent of Lyme disease, Borrelia burgdorferi, is a highly neurotropic organism that not only can produce symptomatic neurologic disease but also can exist dormant within the central nervous system (CNS) for long periods. Two distinct types of neuroborreliosis occur at different stages of Lyme disease. Second-stage Lyme meningitis resembles aseptic meningitis and is often associated with facial palsies, peripheral nerve involvement, and/or radiculopathies. Lyme meningitis may be the first evidence of Lyme disease, occurring without a history of erythema chronicum migrans or flu-like illness. Third-stage parenchymal involvement causes a multitude of nonspecific CNS manifestations that can be confused with conditions such as multiple sclerosis, brain tumor, and psychiatric derangements. Manifestations of CNS parenchymal involvement in Lyme disease are generally associated, however, with a history of erythema chronicum migrans, meningitis, or carditis. Both second- and third-stage Lyme neuroborrelioses are commonly misdiagnosed because they are relatively uncommon and because they mimic many better-known disorders.
PMID: 2682960 [PubMed - indexed for MEDLINE]

Get it? LYME/BORRELIOSIS IS A “STEALTH PATHOGEN” and NOT A KNEE DISEASE.

It is classified as a CHRONIC DISABLER, in bioweapons terminology. This we learned from McSweegan.

Now if Lyme borreliosis has any bioweapons value, and I am not saying it does just because McSweegan thinks so, what exactly would be the point in trying to keep a secret that is no secret? Doesn’t that make you all appear to be extremely STUPID?

Who are you or anyone else intending to use it on? Can’t we simply wipe out the Chinese with a bird flu and starve them to death or something? And doesn’t the American Enterprise Institute hate black people so much that they invented “Custodial Democracy” and tried to export that to Britain? And isn’t it true that the HIV virus transmits congenitally at a 5 times higher rate in black people than in whites or Asians? It is.

So what is the big frickin deal? We should be more worried about Bush wanting to nuke a country surrounded by 87 million geologic fault lines and that is subject to earthquakes anyway. What does this idiot in the White House think is going to happen if he slams Iran with small nukes or Bunker Busters, or Divine Strake, or whatever is the name is the newest “Securing the Realm” NeoCon insanity?

Don’t we have more important things to worry about, like, oh, Tsunamis and Hurricanes?

Or China and Russia having had enough of our belligerent NeoCon BULLSHIT?

In the Name of God, let Lisa go or I will blab some more about US weapons. I’ll do a video on thermite, steel, and the acceleration due to gravity- as if 9/11 wasn’t obvious.

Katheen M. Dickson

23 Garden Street

Pawcatuck, CT 06379

http://actionlyme.org

860-599-5451