For 2 months the NIH, CDC, Yale, and IDSA have REFUSED to answer "What Is OspA?"

"Top Scientist" Anthony Fauci does not know what OspA is, but then again, US News and World Report has become another Israeli Rag. Oh, and by the way, Mort Zuckerman is a sponsor of the Israeli criminal ALDF.com gang.

http://www.washingtonpost.com/wp-dyn/content/video/2009/02/12/VI2009021203091.html

Meanwhile, according to the famous plan of the NIH to hook up with BigPharma to market half-dead drugs, no one mentions the fact that Fauci owns a patent for the treatment of immune suppression outcomes of fungal infections or exposure to Osp-A:

"Illustrative of specific disease states in treatment of which the present invention can be applied are HIV infection and other diseas...es characterized by a decrease of T-cell immunity, for example, mycobacterial infections like tuberculosis and fungal infections such as cryptococcal disease."

http://patft.uspto.gov/ 5696079

United States Patent: 5696079

patft.uspto.gov

A method for activating a mammalian immune system entails a series of IL-2 administrations that are effected intermittently over an extended period. Each administration of IL-2 is sufficient to allow spontaneous DNA synthesis in peripheral blood or lymph node cells of the patient to ..

120516; Uncle Sam Magoo says: "Nevermind the relationship between

"1) vaccines-induced 'autism' (activated viruses from fungal contamination or vaccination of immunosuppressed children),
2) the chronic Lyme-like disease caused by OspA (triacyl lipopeptide TLR2/1 agonist) vaccination, and
3) the fact that TNF-blocking immunosuppression therapy have the same, reactivated-viruses outcomes"

Immunosuppression therapy and resultant reactivation of herpes/viral infections mimic the Chronic/Fatigue/Chronic Lyme outcomes of LYMErix vaccination:

Tumor necrosis factor blockade and the risk of viral infection.
http://www.ncbi.nlm.nih.gov/pubmed/20142812

And Uncle Sam Magoo also says, "Nevermind the fact that 20% of the child deaths globally are due to the fact that there can never be a vaccine made out of a fungal antigen (see the 'Famous Harvard Business School/Mormon Religion' article in WaPo, below) like LYMErix or OspA and that we should have been told that 20 years ago, when Allen Steere falsified the testing for Lyme in Europe, alone, in order to falsify the OspA vaccine outcomes."

"Nevermind the fact that Yale, et al, - the Lyme criminals formally known as ALDF.com (a commercial enterprise) and now known as IDSociety.org - are now responsible for all those 20 years of 20% of child-lives lost because they lied about Lyme and LYMErix...."

120515 On Leadership: If Harvard were a religion
http://www.washingtonpost.com/national/on-leadership/if-harvard-business-school-were-a-religion-it-could-be-mormonism/2012/05/11/gIQA04biIU_story.html

If Harvard Business School were a religion, it could be Mormonism
www.washingtonpost.com
There are leadership values that deeply underpin the Mormon faith — and they’re the same ones taught at Harvard Business School.

Maybe we could get someone from HBS to ASK the NIH what OspA (the LYMErix vaccine that was ordered off the market by the FDA) is? Since we know that that is the "right question" (read the article).

When we ask, we're thrown in jail or threatened with jail - directly, by NIH Director Francis Collins' office (read more about that below).

OKAY, HERE IS MY LETTER TO HARVARD BUSINESS SCHOOL - THE AUTHOR OF THE REPORT ABOVE in WaPo "ON LEADERSHIP", linked above, Clay Christenson:

To: esnyder@hbs.edu

Cc: sr393d@nih.gov, francis.collins@nih.gov, "Allen,Marin (NIH/OD) [E]" <AllenM1@mail.nih.gov>, zach_dann@blumenthal.senate.gov, francis.collins@nih.gov, "Strikas,Raymond A. (Ray) (CDC/OID/NCIRD)" <ras8@cdc.gov>, olib@od.nih.gov, afauci@niaid.nih.gov, joseph.breen@nih.gov, michael.greenwood@yale.edu, richard.horton@lancet.com, astrid.james@lancet.com, spinlyme@yahoogroups.com, m.zecevic@lancet.com, ideditorial@lancet.com, Lawrence.Tabak@nih.gov, pgauwaerter@gmail.com

Subject: WaPo "On Leadership" and the NIH's Threats for "Asking the Right Question"

Date: May 15, 2012 9:06 AM
Dear Sir,

Regarding your article on Leadership in WaPo:
http://www.washingtonpost.com/national/on-leadership/if-harvard-business-school-were-a-religion-it-could
-be-mormonism/2012/05/11/gIQA04biIU_story.html

We were wondering if you could "ask the right
question" for us to the NIH (Francis Collins
and Anthony Fauci would be fine).

No one at the NIH, CDC, Yale or IDSociety.org
has been able to answer the question of what
exactly the Lyme vaccine (LYMErix or ImmuLyme)
was. Of course we know they were "recombinant
lipoproteins of Outer Surface Protein A of
the Lyme spirochete," but we wanted to know its
***exact structure,*** since as you know, Structure
Equals Function.

When I called last Friday (a week ago), Francis
Collins' little secretary would not allow me to
speak - I merely wanted to give her the results of
Collins referrals to others at the NIH to ASK
what was OspA - She instead blurted out that
she would call the police if I kept asking the
NIH what was that vaccine that the CDC and NIH
said was a vaccine:
http://edition.cnn.com/TRANSCRIPTS/0306/20/ldt.00.html

"We've had an effective vaccine, but it's the kind of vaccine that you have to essentially vaccinate people each year. And from the standpoint of it's use, it has not been used as efficiently as it could have been used. So scientifically, we had a vaccine and still do have a vaccine, but it's not really well used." -- Anthony Fauci

That OspA vaccine was ordered removed from the
market in 2002 when Karen Forschner of the
Lyme Disease Foundation (Hartford, CT) presented
the FDA with a patent owned by Denise Huber at
Tufts indicating that OspA "bound the HLA molecule"
or was technically a toxin for people who have
the (only) genetic background that tests positive for
"Lyme Disease" (as redefined in Dearborn, Michigan
in 1994, in a "consensus" conference held by the
CDC).

Meanwhile, for the people who do not have the
new, Dearborn, 1994 definition of Lyme "hypersensitivity"
or "binds the HLA molecule" (inferring a binding
of the antigen-presenting molecule with greater
energy or kinetics, producing a toxin, itself
as the complex of HLA-antigen), ***there is another
outcome from the chronic exposure to OspA,*** either
from vaccination (the regimen for the vaccines
experiments was 3 injections of the OspA vaccines)
or from the autovaccination of spirochetal
blebbing.

[Blebbing is to a spirochete what shedding
is to a dog; by merely having a chronic infection
with spirochetes - and all spirochetal infections
throughout history are known to be chronic, a Lyme
victim is subject to this autovaccination or
shedding or blebbing.]

In other words, the other outcomes of chronic
exposure to OspA were the definitions of "Lyme
Disease" that were left out of the Dearborn
"consensus" conference definition - the outcomes
of chronic Lyme previously identified by Yale
and the IDSociety.org in their journal, "Infectious
Disease Reviews," or the New Great Imitator outcomes
of MS, Lupus, ALS, and similar neurological outcomes
that seem to be associated with B cell mutations
that look like Epstein-Barr reactivation.

It turns out that over the years, there is nothing
but more and more additive scientific evidence that
something about this fungal antigen, OspA, mutes the
immune response, produces no antibodies (interferes with
antibody production), and seems to act in synergy
with viruses like Epstein-Barr (EBV), in that both OspA
and EBV either donate to or add to anti-apoptosis of
an infected cell.

Now, meanwhile I remind you that there is no Tuberculosis
vaccine or HIV vaccine, because these vaccines that
were similar to LYMErix produced the same outcomes
as the LYMErix trials: increased susceptibility to
infection and no antibodies.

You can go ahead and look that up or ask someone at
Harvard. I assume there will be someone at Harvard
who can show you how to use the PubMed database.

But, as you know, there is today another outcry apparently
by vaccine manufacturers supported by the CDC [since
the CDC does nothing more than support vaccine
manufacturers, even going so far as to co-own 5
patents with SmithKline in Europe from 1992, wherein
they identify the 2 distinct outcomes of Lyme: 1) the
hypersensitivity or allergy or "bad knees" response
and 2) the non-"bad-knees" response or the cases of
Lyme that do not test positive according to the CDC's
1994, falsified (even if we just judged the outcome
of the conference on the basis of consensus, since
there was no consensus, not even close) Dearborn criteria]
about the high rate of death in children because
there is no Pneumonia vaccine.

Daily Disruption – Study: Pneumonia Leading Cause of Death Among Children Under The Age of 5 -..
http://www.dailydisruption.com/2012/05/study-pneumonia-leading-cause-of-death-among-children-under
-the-age-of-5/

Pneumonia is MYCOBACTERIA pneumonia.

Get it?

No fungal vaccines?

Not whether they were apparently the HIV-LYMErix
or the TB-LYMErix or the MRSA-LYMErix. They all
failed.

Now, don't you think it is odd that the NIH and CDC
refuse to answer our question as to what OspA was?

Maybe you could show us some of that Mormon-Harvard
Leadership and ask the right question on our behalf:
"What Is OspA?

Since it failed so many times and is associated
with so many medical failures, not the least of
which are all the myco-contaminated childhood
vaccines that give the result we like to call
Autism:

1) "Finally, there is the risk that the virus may not be fully or completely inactivated or attenuated and thus, the vaccine may actually cause disease."
http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%
2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=7%2C632%2C510.PN.&OS=PN%2F7
%2C632%2C510&RS=PN%2F7%2C632%2C510

2) Measles, Mumps, and Rubella -- Vaccine Use and Strategies for Elimination of Measles, Rubella, and Congenital Rubella Syndrome and Control of Mumps: Recommendations of the Advisory Committee on Immunization Practices (ACIP)
http://www.cdc.gov/mmwr/preview/mmwrhtml/00053391.htm

"Updated information on adverse events and contraindications, particularly for persons with severe HIV infection, persons with a history of egg allergy or gelatin allergy, persons with a history of thrombocytopenia, and persons receiving steroid therapy [are immunosuppressed- KMD]."

3) CDC: Human Exposure to Brucella abortus Strain RB51 -- Kansas, 1997
http://www.cdc.gov/mmwr/preview/mmwrhtml/00051495.htm

An ^^^ immunosuppressed pregnant cow was given a Brucella (LYMErix-like) "live attenuated" vaccine and the baby cow ended up with the disease, which then was transferred to the humans handling the cow and her dead baby. This parallels what is happening to children who are vaccinated while immunosuppressed, or who receive mycoplasmally (LYMErix-like) contaminated vaccines.

4) in the case of pandemic MRSA, as we have seen, the vaccine didn't work because TLR2 agonists (lipoproteins) suppress the immune system. We also learned from the MRSA vaccine patent, that:

"Several established vaccines consist of live attenuated organisms where ***the risk of reversion to the virulent wild-type strain exists. In particular in immunocompromised hosts this can be a live threatening scenario.*** Alternatively, vaccines are administered as a combination of pathogen-derived antigens together with compounds that induce or enhance immune responses against these antigens (these compounds are commonly termed adjuvant), since these subunit vaccines on their own are generally not effective."
http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%
2Fnetahtml%2FPTO
%2Fsrchnum.htm&r=1&f=G&l=50&s1=7,771,728.PN.&OS=PN/7,771,728&RS=PN/7,771,728

---------------------------------------------------------

WaPo and the Harvard Business School and
the Mormons call this Leadership. When
American Government's Crime Victims
ask the right question, we're thrown and
jail and threatened with jail.

This is the opposite of leadership, but
cowardice.

I hope you can put your money where your
Mormon/HBS mouth is and ask Francis Collins
what OspA is and get back to us.

Thank you.

Kathleen M. Dickson
former Pfizer Analytical Methods
and Validations chemist

120514; Monday Criminal REtard Uncle Sam Magoo Update:

The primary, dominant global science says that LYMErix (OspA) could never have been a vaccine. And if so, what are we to make of IDSociety.org's and the CDC's position on "Lyme" or anything else ?

The current "Lyme Program Officer" at the NIAID (under Anthony Fauci) agreed with me that flagellin from all the Relapsing Fever borrelia is the only sane (valid) antibody test for "Lyme."

Given that fact, there are no "guidelines."

New old-news on immunosuppression (including no-antibodies) caused by Lyme and LYMErix:

Macrophage p38 MAP Kinase Activity Regulates iNK Cell Responses During Infection with Borrelia burgdorferi...

Previously, we learned from Ray Dattwyler in 1988, regarding this same NK cell activity inhibition:

Ray Dattwyler (1988):

Other Lyme Immunosuppression News:

Delays and Diversions Mark the Development of B Cell Responses to Borrelia burgdorferi Infection.

("Uh, what? Lyme is not 'an autoimmune T cell disease?' It's a B-cells-are-effed-disease? What's that you say?")

Other, related news

("Oh, Ya mean fungal (pneumonia) antigens like OspA or LYMErix can't be made into a vaccine? Oh."):

Daily Disruption – Study: Pneumonia Leading Cause of Death Among Children Under The Age of 5 -..
www.dailydisruption.com
Pneumonia is the leading cause of death among children under 5, according to a new study led by researchers at the Johns Hopkins Bloomberg School of Public Health. They examined the distribution of child deaths globally by cause in 2010 and found that 64 percent were attributable to infectious caus...
More Old News on How LYMErix Could Never Have Been a Vaccine, from the UK:

J Infect Dis. 2010 Jun 1;201(11):1753-63.

Bacterial lipoproteins differentially regulate human primary and memory CD4+ T and B cell responses to pneumococcal protein antigens through Toll-like receptor 2.

Zhang Q, Bagrade L, Clarke E, Paton JC, Nunez DA, Finn A.

Source
Department of Cellular and Molecular Medicine, University of Bristol, Bristol, UK. qibo.zhang@liv.ac.uk

Abstract

BACKGROUND:

Bacterial lipoproteins (BLPs) [like LYMErix] are expressed across a range of bacteria and are able to activate Toll-like receptor 2 (TLR-2). BLPs enhance immune responses in naive individuals and have therefore been tested as candidate vaccine adjuvants. It is not known whether BLPs affect any preexisting immunity (eg, memory cell response in primed individuals). Colonization with pneumococcus (PNC), which primes for memory cell response, is common in young children.

METHODS:

We studied effects of BLPs on memory and primary B and CD4+ T cell responses to pneumococcal proteins using adenoidal cells from children.

RESULTS:

Although BLPs enhanced the primary antibody responses seen in some children with no detectable nasal PNC, BLPs unexpectedly reduced the memory antibody responses in children with positive nasal culture results. Likewise, BLPs augmented the naive but inhibited the memory antigen-driven CD4+ T cell response. The downregulation of the memory responses was associated with increases in interleukin 10 and inducible costimulatory molecule expression, as well as a decrease in CD28 expression in memory CD4+ T cells; all were blocked by anti-TLR2 and anti-B7h antibodies. Augmentation of naive CD4+ T cell proliferation was blocked by anti-B7.2.

CONCLUSION:

Differential regulation of primary and memory responses by BLPs through TLR2 may have important implications for therapeutic and vaccination strategies against bacterial infection. [Like the definition of "Lyme Disease, which was falsified in order to falsify LYMErix as a BLP "vaccine" - the intention of which is to produce antibodies]

http://jid.oxfordjournals.org/content/201/11/1753.long

But in the fact that Lyme is not an inflammatory disease and LYMErix therefore could never have been a vaccine, Yale is not interested. It has zero to do with penises, which are Yale's and the State of Connecticut's only topic. I am sorry to say that Yale has no topics. But Yale itself, with its no-topics is an anthropological topic:
Eugenics: the skeleton that rattles loudest in the left's closet

gu.com

Jonathan Freedland: Socialism's one-time interest in eugenics is dismissed as an accident of history. But the truth is far more unpalatable
Yale would have had to learn about the kind of autism Einstein had - it is associated with Neurofibromatosis. I can tell you with certainty Yale rejected this information when I gave to them.

It has to do with a reversed duplication of a BCL-2 class gene and has similarities with the mechanisms of dysimmunity associated with "Lyme Disease" (OspA) in that both OspA and the Epstein-Barr it activates promote or contain BCL-2 genes or anti-apoptotic behavior.

A reversed duplication of a BCL-2 like gene results in the inhibition of normal synaptic pruning (large brains), I gave this information to Yale and the State of Connecticut in 2003. (It was already published in the journals.)

How could anyone at Yale even attempt to or pretend to create a race of very smart people, when they themselves have no idea what smart is? It's like watching a bird try to train an elephant. It's very funny. Yale does not want the information they would need to create the New Aryans.

They still don't.

Yale staff have no creative talent or ability. By their fruits shall you know them.

120514, KMDickson

Uncle Sam Magoo's School of Driving and Health dot gov

Funny! Nobody employed by Uncle Sam knows anything, so with what would we be indoctrinated? LMAO!!

Alleged US Army doc: re-education camps and psy-op missions aimed at activists
www.globalresearch.ca
An American military document just uncovered appears to detail an US Army plan that calls for detaining political activists at re-education camps staffed by military-hired PSYOP officers in both America and abroad.

Alleged US Army doc: re-education camps and psy-op missions aimed at activists
http://rt.com/usa/news/psyop-activists-internment-resettlement-526/

We're gonna hear all about how the moon is made of green cheese, LYMErix was a vaccine,...

Meanwhile....

120504: Frankie (Collins) & Tony (Fauci) in the Hot Seat: Medical News: FDA, NIH Respond to Charges of Lax Oversight - in Washington-Watch, Washington Watch f

I called Francis Collins' (NIH Director) office this AM to leave a message that "No one in the NIH and CDC will answer the question as to what OspA is," and then leave it at that for Collins to follow up. Collins' office previously referred me to NIAID, who could not answer the question. His secretary then said this to me:

"We're asking that you no longer contact this office and we will be forwarding you to the police after this call," and then the secretary hung up.

There ya go. Cowardice drives all US "government" operations. They're obviously pretty damned scared of being put on the spot over OspA and "Lyme." Excellent.

What OspA does, is the disease. And it's not inflammation, but a form of AIDS.

The NIH refuses to answer because then you would see 200,000 instantaneous lawsuits against Yale, Tufts, NYMC, New Joisey Medical and Dental ....

That would be the end of Yale's Endowment fund. Their Endowment fund funded L2 Diagnostics - Schoen's RICO operation with Corixa and Imugen. All of that was based on the lie of LYMErix.

They're terrified of everyone discovering that ***they're all up for murder charges.***

Especially Allen Steere and Robert Schoen over the Dearborn standard and falsifying the LYMErix outcomes.

Gary Wormser and Mark Klempner, too, over the "guidelines."

Wormser is an easy one to charge with murder because he so clearly said Dearborn only detected 15% of the cases in IgG:

http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=266355&blobtype=pdf (read carefully, he specifically states that he is assessing Steere's IN EUROPE proposal, where he leaves OspA and B out of the standard and uses high-passage strains)

That's definitely a homicide charge and not a negligent homicide charge because of all the subsequent slander, libel and perjury against Lyme victims. The lies told, and the aggression towards us fits the USDOJ's criteria of RICO.

They act exactly like the mafia.

And now you see that Francis Collins is part of that mob.

The LYMErix Story:

Ian Malcolm: I'll tell you the problem with the scientific power you're using here: it didn't require any discipline to attain it. You read what others had done, and you took the next step. You didn't earn the knowledge for yourselves, so you don't take any responsibility for it. You stood on the shoulders of geniuses to accomplish something as fast as you could, and before you... even knew what you had, you, you've patented it, and packaged it, you've slapped it on a plastic lunchbox, and now
[pounds table with fists]
Dr. Ian Malcolm: you're selling it.
[pounds table again]
Dr. Ian Malcolm: You want to sell it, well...
John Hammond: I don't think you're giving us our due credit. Our scientists have done things which nobody's ever done before...
Dr. Ian Malcolm: Yeah, but your scientists were so preoccupied with whether they could that they didn't stop to think if they should.

Lipopolysaccharide Binding Protein Binds to Triacylated and Diacylated Lipopeptides and Mediates Innate Immune Responses¹

"The strong proinflammatory capacities of lipoproteins were first described for outer surface proteins A and B of Borrelia burgdorferi, which are also highly immunogenic (17) and have lately been the basis for a Lyme disease vaccine development (18). These compounds exhibit an triacylated lipid anchor structure comprising an N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteinyl (Pam₃Cys) moiety at the N terminus (19), a feature that was previously described for the Braun lipoprotein from Escherichia coli (20). Because the N-terminal Pam₃Cys modification is essential for immunoactivation caused by lipoproteins of B. burgdorferi as well as of another spirochete, Treponema pallidum (21), subsequent studies investigating immune responses to spirochetes used synthetic lipopeptides (22). The Pam₃Cys moiety was also reported to be present in cytokine-inducing lipoproteins of Mycobacterium and Mycoplasma spp. (23, 24); thus, it can be regarded as a highly conserved molecular motif among different classes of bacteria."
http://www.jimmunol.org/content/173/4/2683.long

and, here we see Pam3Cys HIV, SIV:

"We are currently using several mass spectral techniques to characterize the amino acid sequences of the Pam3Cys peptide found in the envelop glycoproteins of HIV-1 and the Simian Immunodeficiency Virus (SIV) 17. Conventional fast-atom bombardment-mass-spec analysis using standard matrices, such as glycerol and nitrobenzyl alcohol, is nor particularly effective for these molecules, largely due to their tendency to aggregate."

full text at: http://www.actionlyme.org/PAM3CYS_IMMUNE_SUPPRESSION.htm

and

The people who wrote the following report cited bioweaponeer Joe Tully from 1963, talking about mycoplasma, fatigue and erythrocytes. 'Totally on the money with Lyme and HIV bearing the same types of immunosuppressing molecules:

Immunological response of rodents to murine myc... [Infect Immun. 1970] - PubMed - NCBI

"A positive correlation was demonstrated between ability of the mycoplasma to induce disease and lack of MI antibody formation by its natural host. It is suggested that the apparent inability of the various animals to produce MI antibodies against their natural mycoplasmal parasites may enable the mycoplasmas to become established in their hosts."
http://www.ncbi.nlm.nih.gov/pubmed/16557855

ERYTHROCYTE-MODIFYING CAPACITY AND SEROLOGICAL REACTIVITY OF CELL COMPONENTS OF HUMAN MYCOPLASMA (PPLO) STRAINS.
http://www.ncbi.nlm.nih.gov/pubmed/14120330

And soon thereafter, a seronegative, Mycoplasmal-antigen bearing, chronic fatigue-causing modified Borrelia showed up 10 miles from Plum Island.

Other reports that cited 1963 Joe Tully - a well-known bioweaponeer - on seronegative, fatigue-causing mycoplasma in the blood:
http://www.ncbi.nlm.nih.gov/pubmed?db=pubmed&cmd=link&linkname=pubmed_pubmed_citedin&uid=14120330

Mycoplasmal, OspA-like, HIV-like antigens cause seronegative disease. Get it? 1963.

Later, of course, Ray Dattwyler in 1988 found the same thing re fungal infections and... Lyme Borreliosis.

Pope: Evil people are not going to be too good at science:

"the decline of thought and the weakening of the capacity of intelligence for what is real."

Pope tells medical faculty: restore role of faith in research : News Headlines - Catholic Culture

We knew that.

More on Stupid Science at BUBBA_HEARTS_ALLEN_STEERE.htm

IDSA's Explanation: "Lyme causes nothing," "no disease outcomes happen from Lyme," "nothing causes anything," "Lyme victims are looney," "Lyme victims have paranoid delusional wannabee diseases," and "Lyme victims are TERRORISTS!!!, But get the mysterious, unknown OspA vaccine."

Confronting "government" "employees" over their scientific incompetence

I sent 2 letters May Day, 2012 to the NIH, CDC, Yale, Francis Collins, Anthony Fauci, Paul Auwaerter, the editors of the Lancet, and so on as you can see below. The whole world can stand by and see if they reply. And by "reply," I mean, answer the "What is OspA" question and answer what they think of the proposed RULE on fungal antigens/vaccines and resultant activated viruses causing the brain damage we call autism:

To: sr393d@nih.gov, francis.collins@nih.gov, AllenM1@mail.nih.gov, zach_dann@blumenthal.senate.gov, francis.collins@nih.gov, ras8@cdc.gov, olib@od.nih.gov, afauci@niaid.nih.gov, joseph.breen@nih.gov, michael.greenwood@yale.edu, richard.horton@lancet.com, astrid.james@lancet.com, m.zecevic@lancet.com, ideditorial@lancet.com, Lawrence.Tabak@nih.gov, pgauwaerter@gmail.com

Cc: spinlyme@yahoogroups.com

Subject: No one at the NIH, CDC, Yale, or IDSA knows what OspA is.

Date: May 1, 2012 4:54 AM

Greetings,

I see that there is a job opening for what looks like
Sally Rockey's job:
http://www.fins.com/Finance/Jobs/212548/Director-Office-of-Policy-for-Extramural-Research-Administration

I am wondering if Ms. Rockey is leaving becuase no one
at the NIH knows what OspA is?

As most of you know, I have been asking around for over a month.

WHAT IS OSP-A (the structure)?

No one at Yale knows.

IDSociety doesn't know.

NIAID doesn't know.

Francis Collins can't/won't answer the question.

Paul Auwaerter's office tells me he does not know.

Lawrence Tabak hasn't answered me.

No one at the CDC knows (despite CDC officers
owning several patents for recombinant antigens
of Borrelia burgdorferi).

Nobody knows what OspA is.

I find this odd, since this vaccine designed the "disease."
Allen Steere left OspA and B out of the diagnostic
standard for Lyme disease using illegal (according to the
NIH Rocky Mountains Lab) "high-passage" strains of Bb
and recombinant antigens of the protein ends of OspA and B
without the lipid attached to leave OspA and B out of the current
CDC diagnostic standard, only to find the Western Blots of OspA-vaccinated
people were unreadable anyway:
http://cid.oxfordjournals.org/content/31/1/42.long
(presumably ^^ because OspA sticks to itself as CDC officer
Alan Barbour once claimed).

The first order of business is the clarification of falsified antibody testing for “Lyme Disease.”
In 1992 Allen Steere went to Germany, with, as he claimed,

“The group 1 strain of B. burgdorferi, G39/40, used in this study and in the previous study of US patients was isolated from an Ixodes damini tick in Guilford, Connecticut [21]. The group 2 strain, FRG [Federal Republic of Germany], was isolated from Ixodes ricinus near Cologne [22]. The group 3 strain, IP3, was isolated from Ixodes persulcatus near Leningrad [23]. All three strains used in this study were high passage isolates, which were classified by Richard Marconi (Rocky Mountain Laboratory, Hamilton, MT) using 16S ribosomal RNA [per the DNA/RNA Shell Game - never used to detect spirochetes in humans after treatment] sequence determination as described [11, 24]. The recombinant preparations of OspA and OspB used in this study were purified maltose- binding protein-Osp fusion proteins derived from group 1 strain B31 [25]. The fusion proteins contained the full-length OspA or OspB sequence without the lipid moiety or the signal sequence -"

-- illegal, plasmid-dropping, antigen-and-antibody dropping, “high passage strains,” and OspA and B with no lipids attached (not likely to produce antibodies), resulting in the new, 1994, Centers for Disease Control (CDC), “case definition” of “Lyme Disease (8, 9)."

Without the lipids attached, the outer surface proteins are
less likely to produce antibodies.

Now, at one time (1991), Allen Steere wrote that
there were 2 outcomes to Lyme: RA and MS.

Currently, only the RA outcome is recognized
(see the CDC's Dearborn definition where only
the HLA-linked hypersensitivity response without
OspA-B is recognized) as a "case."

The basis of the 4.7 million dollar grant that
went to Mark Klempner was to study the 30 day
intravenous ceftriaxone treatment of people
among whom 2/3rds never had had intravenous
ceftriaxone before:
"A total of 42 (33 percent) of the patients had previously received intravenous antibiotic treatment for a mean (±SD) of 30±12 days. All other previous treatment consisted of oral antibiotics."
http://www.nejm.org/doi/full/10.1056/NEJM200107123450202#t=articleMethods

Klempner ^^^ found that 30 days of IV ceftriaxone was
not enough ceftriaxone for people who had never
had ceftriaxone before.

Perhaps no one was looking too closely at
the grant they approved. Klempner found
that the "standard of care" - arbitrarily defined
in the first place - was not enough intravenous
antibiotics for these people.

But that's a tough call, isn't it? You don't
need INTRAVENOUS antibiotics for knee diseases -
the "case definition."

Maybe if we knew what OspA was. After all, it
defined the disease. Both in the classical
commercial sense (the Dearborn definition) and in
Allen Steere's HLA-linked hypersensitivity sense.

A man named Roland Martin left his job at
the NIH once he found out OspA actually caused
the disease he was studying - the MS outcome:
"Borrelia burgdorferi Induces TLR1 and TLR2 in human microglia and peripheral blood monocytes but differentially regulates HLA-class II expression."
http://www.ncbi.nlm.nih.gov/pubmed/16783164
"These results show that signaling through ***TLR1/2*** [note- remember the structure/function relationship-added by KMD] in response to B. burgdorferi can elicit opposite immunoregulatory effects in blood and in brain immune cells, which could play a role in the different susceptibility of these compartments to infection."

and
"Borrelia burgdorferi lipoprotein-mediated TLR2 stimulation causes the down-regulation of TLR5 in human monocytes."
http://www.ncbi.nlm.nih.gov/pubmed/16479520

"Toll-like receptors (TLRs) trigger innate immune responses via the recognition of conserved pathogen-associated molecular patterns. Lipoproteins from Borrelia burgdorferi, the agent of Lyme disease, activate inflammatory cells through TLR2 and TLR1. We show that stimulation of human monocytes with B. burgdorferi lysate, ***lipidated outer surface protein A, and triacylated lipopeptide Pam3CysSerLys4 results in the up-regulation of both TLR2 and TLR1 but the down-regulation of TLR5, the receptor for bacterial flagellin, and that this effect is mediated via TLR2.*** TLR4 stimulation had no effect on TLR2, TLR1, and TLR5 expression. Human monocytes stimulated with TLR5 ligands (including p37 or flaA, the minor protein from B. burgdorferi flagella) up-regulated TLR5. ***In addition, TLR2 stimulation rendered cells hyporesponsive to a TLR5 agonist.*** These results indicate that diverse stimuli can cause differential TLR expression, and we hypothesize that these changes may be useful for either the pathogen and/or the host."

I hypothesize that TLR2/1 agonists suppress
the immune response and that everything Mark
Klempner and IDSA, Yale, and the CDC say is
garbage.

What do you say?

Anyone?

Anyone know what OspA is?

The CDC to this day maintains that it is
a vaccine. NIH never retracted their statement
that it was.

My personal observation is that, like Roland
Martin is revealing, OspA caused the seronegative
neurological disease outcome sometimes called
Multiple Sclerosis - the job he was hired to study
at the NIH.

OspA does something to the immune system that
is not like what Allen Steere and the CDC claim
with their "case definition."

And MS is largely recognized to be caused
by Epstein-Barr/Similar herpes viruses.

Hmmm.

It would be nice to know what OspA is.

We might be able to end the OspA-linked
"controversy."

Kathleen M. Dickson
former Pfizer Analytical
Methods Development and Validation
chemist.